A decision analytic model to guide early-stage government regulatory action: Applications for synthetic biology

Synthetic Biology for Therapeutic Applications

Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and ...

Modeling screening, prevention, and delaying of Alzheimer's disease: an early-stage decision analytic model

BACKGROUND Alzheimer's Disease (AD) affects a growing proportion of the population each year. Novel therapies on the horizon may slow the progress of AD symptoms and avoid cases altogether. Initiating treatment for the underlying pathology of AD would ideally be based on biomarker screening tools identifying pre-symptomatic individuals. Early-stage modeling provides estimates of potential outco...

A Stage Model for E-Government Implementation

A Decision Support System for Local Government Regulatory Advice

This paper describes the implementation of a decision support system that helps non-technical front-line reception staff handle complex enquiries on a wide range of local government regulations. The paper describes the knowledge ngineering and the knowledge level modelling undertaken for the prdject. The paper describes the design, implementation and architecture of the resulting distributed sy...

Synthetic biology platform technologies for antimicrobial applications.

The growing prevalence of antibiotic resistance calls for new approaches in the development of antimicrobial therapeutics. Likewise, improved diagnostic measures are essential in guiding the application of targeted therapies and preventing the evolution of therapeutic resistance. Discovery platforms are also needed to form new treatment strategies and identify novel antimicrobial agents. By app...